Non-monotonic Response to Monotonic Stimulus: Regulation of Glyoxylate Shunt Gene-Expression Dynamics in Mycobacterium tuberculosis
نویسندگان
چکیده
منابع مشابه
Non-monotonic Response to Monotonic Stimulus: Regulation of Glyoxylate Shunt Gene-Expression Dynamics in Mycobacterium tuberculosis
Understanding how dynamical responses of biological networks are constrained by underlying network topology is one of the fundamental goals of systems biology. Here we employ monotone systems theory to formulate a theorem stating necessary conditions for non-monotonic time-response of a biochemical network to a monotonic stimulus. We apply this theorem to analyze the non-monotonic dynamics of t...
متن کاملNon-monotonic dose-response relationship in steroid hormone receptor-mediated gene expression.
Steroid hormone receptors are the targets of many environmental endocrine active chemicals (EACs) and synthetic drugs used in hormone therapy. While most of these chemical compounds have a unidirectional and monotonic effect, certain EACs can display non-monotonic dose-response behaviors and some synthetic drugs are selective endocrine modulators. Mechanisms underlying these complex endocrine b...
متن کاملProlegomena to Logic Programming for Non-monotonic Reasoning Prolegomena to Logic Programming for Non{monotonic Reasoning
The present prolegomena consist, as all indeed do, in a critical discussion serving to introduce and interpret the extended works that follow in this book. As a result, the book is not a mere collection of excellent papers in their own specialty, but provides also the basics of the motivation, background history, important themes, bridges to other areas, and a common technical platform of the p...
متن کاملGlyoxylate Shunt: Combating Mycobacterium at forefront
Perpetual survival of Mycobacterium inside immunologically educated host is puzzle unsolved. The survival strategy breeds a stage at which the bacterium undergoes a metabolic arrest. They initiate lipid lunch by triggering glyoxylate shunt, a metabolic salvage strategy to combat hostile dynamics of host macrophase. Here, I highlight the plethora of functions that the enzyme of the pathway exhib...
متن کاملAnalysis of Algorithms for Monotonic and Non-Monotonic Reasoning
i Preface Logic has always provided a rigorous foundation for mathematics and philosophy, and more recently it has been called upon to support formal concepts and problem-solving mechanisms for computer science, operations research, and artificial intelligence. Recent work emphasizes that, in addition to traditional concerns such as soundness and completeness of proof systems, it is important t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLOS Computational Biology
سال: 2016
ISSN: 1553-7358
DOI: 10.1371/journal.pcbi.1004741